The Help Library / Anti-HIV Enzyme Inhibition Data
Field Names:
The enzyme or receptor which an inhibitor or activator is tested against. (Should not be confused with target.)
This database contains values against cellular and viral enzymes.
A list of enzymes is provided in the database. To access this list choose ENZYME from the Field dropdown menu. A link containing a list of enzymes will appear on the right.
*The fields returned in a chemical compound search include: Chemical Name, Synonyms, Classes, Company, links to PubMed, ChemID Plus, anti-HIV In-Vitro, Enzyme Inhibition, or Anti-Opportunistic Infection Data.
The target is generally the species or cellular process at which the inhibitor or drug is targeted in an enzyme or cellular anti-viral assay aimed at inhibiting or preventing HIV proliferation. A list of targets can be accessed from the main search page by clicking on the'Anti-HIV Cell-Based Data' link, or the 'Anti-HIV Enzyme Inhibition Data' link, selecting the'TARGET' field and then clicking on the 'target examples' link. To search by a particular target double-click on the name of that target on the list or type the name of a target in the target entry box.
*The fields returned in a chemical compound search include: Chemical Name, Synonyms, Classes, Company, links to PubMed, ChemID Plus, anti-HIV In-Vitro, Enzyme Inhibition, or Anti-Opportunistic Infection Data.
Field Names:
For example: many nucleoside inhibitors are tested against reverse transcriptase or cellular DNA polymerases.
Enzymes are listed in ascending alphabetical order.
*The fields returned in a chemical compound search include: Chemical Name, Synonyms, Classes, Company, links to PubMed, ChemID Plus, anti-HIV In-Vitro, Enzyme Inhibition, or Anti-Opportunistic Infection Data.
*The fields returned in a chemical compound search include: Chemical Name, Synonyms, Classes, Company, links to PubMed, ChemID Plus, anti-HIV In-Vitro, Enzyme Inhibition, or Anti-Opportunistic Infection Data.
HIV Strain Type
Subgroup of HIV species (also called taxon).
Two types of HIV have been characterized in humans, HIV-1 and HIV-2.
HIV-2 is less common than HIV-1 and is mainly found in West Africa.
Subtypes A and C are the most common, accounting for about one-half of HIV-1 infections world-wide.
In Canada, the United States and Western Europe, HIV-1 subtype B predominates. However, due to travel and migration, non-B subtypes are increasingly being reported in these parts of the world.
*The fields returned in a chemical compound search include: Chemical Name, Synonyms, Classes, Company, links to PubMed, ChemID Plus, anti-HIV In-Vitro, Enzyme Inhibition, or Anti-Opportunistic Infection Data.
The general category assigned to a chemical based on toxicity, use pharmacology, or status in certain chemical lists.
A list of compound classes is provided in the database. To access this list choose Class from the Field dropdown menu. A link containing a list of classes will appear on the right.
*The fields returned in a chemical compound search include: Chemical Name, Synonyms, Classes, Company, links to PubMed, ChemID Plus, anti-HIV In-Vitro, Enzyme Inhibition, or Anti-Opportunistic Infection Data.
HIV strain types are listed in ascending numerical order and, subsequently, ascending alphabetical order.
*The fields returned in a chemical compound search include: Chemical Name, Synonyms, Classes, Company, links to PubMed, ChemID Plus, anti-HIV In-Vitro, Enzyme Inhibition, or Anti-Opportunistic Infection Data.
Compound classes are listed in ascending alphabetical order.
*The fields returned in a chemical compound search include: Chemical Name, Synonyms, Classes, Company, links to PubMed, ChemID Plus, anti-HIV In-Vitro, Enzyme Inhibition, or Anti-Opportunistic Infection Data.